STING Polymer Structure Reveals Mechanisms for Activation, Hyperactivation, and Inhibition
In our polymer structure of the cGAMP:G230A STING complex, the homodimer''s total surface area is 29,600 Å 2 with 8,640 Å 2 buried in the polymer interface. At this interface, Asp301 from one STING dimer is positioned in between Arg281 and Arg284 from the neighboring dimer and can form a salt bridge with either residue depending on its